The 58th AESGP Annual Meeting – the annual gathering of the self-care sector in Europe – was held on 7-8 June in Madrid, Spain. The Annual Meeting was the first face-to-face AESGP conference since the start of the COVID-19 pandemic. It brought together industry leaders and representatives of partner organisations and decision-makers to explore key trends that are transforming the landscape of the self-care industry. Two years after the start of the COVID-19 pandemic, we continue to live in a world full of uncertainties. The AESGP Annual Meeting thus explored how to support innovation in these challenging times and how to translate these challenges and uncertainties into opportunities for the self-care sector.